Article

Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response

2021-06-28

Abstract excerpt

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family, may have off-target effects genome-wide, but its effects at pan-cancer level are not well elucidated. Here, we used different pan-cancer datasets, totaling more than 50,000 samples analyzed by whole-genome, whole-ex...

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Literature Corpus work: ed70711c-53e2-56d9-938c-b01f1c9b5109
DOI: 10.1101/2021.06.26.447715

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