Article
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.
Nature reviews. Immunology - 1 Mar 2016
Casellas Rafael, Basu Uttiya, Yewdell William T, Chaudhuri Jayanta, Robbiani Davide F, Di Noia Javier M
Abstract excerpt
As B cells engage in the immune response, they express activation-induced cytidine deaminase (AID) to initiate the hypermutation and recombination of immunoglobulin genes, which are crucial processes for the efficient recognition and disposal of pathogens. However, AID must be tightly controlled in B cells to minimize off-target mutations, which can drive chromosomal translocations and the development of B cell...
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