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Article

High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif.

Scientific reports - 25 Oct 2017

Tsukamoto Taku, Nakano Masakazu, Sato Ryuichi, Adachi Hiroko, Kiyota Miki, Kawata Eri, Uoshima Nobuhiko, Yasukawa Satoru, Chinen Yoshiaki, Mizutani Shinsuke, Shimura Yuji, Kobayashi Tsutomu, Horiike Shigeo, Yanagisawa Akio, Taniwaki Masafumi, Tashiro Kei, Kuroda Junya

Abstract excerpt

We investigated clinical and genetic characteristics of high-risk follicular lymphoma (FL), that lacked evidence of large cell transformation at diagnosis, in the rituximab era. First, we retrospectively analysed the clinical features of 100 patients with non-transformed FL that were consecutively treated with rituximab-containing therapies in a discovery cohort. The presence of either peripheral blood and/or...

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Identifiers

PMID: 29070849
DOI: 10.1038/s41598-017-14150-0
PMCID: PMC5656578

Genes

BCL2

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