Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas.

The Journal of experimental medicine - 1 Feb 2021

Ye Xiaofei, Ren Weicheng, Liu Dongbing, Li Xiaobo, Li Wei, Wang Xianhuo, Meng Fei-Long, Yeap Leng-Siew, Hou Yong, Zhu Shida, Casellas Rafael, Zhang Huilai, Wu Kui, Pan-Hammarström Qiang

Abstract excerpt

Both somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase (AID). Dysregulation of these processes has been linked to B cell lymphomagenesis. Here we performed an in-depth analysis of diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) genomes. We characterized seven genomic mutational signatures, including two B cell tumor-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytidine Deaminase
Share to Immunoglobulin Class Switching

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

Share to Somatic Hypermutation, Immunoglobulin

Source

Open in PubMed Open full text

Identifiers

PMID: 33136155
DOI: 10.1084/jem.20200573
PMCID: PMC7608067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas.PMID 33136155Read ↗

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.Semantic proximity Read ↗

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.Semantic proximity Read ↗

High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif.Semantic proximity Read ↗

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease ProgressionSemantic proximity Read ↗

Somatic hypermutation mechanisms during lymphomagenesis and transformation.Semantic proximity Read ↗

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphomaSemantic proximity Read ↗

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma.Semantic proximity Read ↗

AID Shapes Proliferation and Cell-of-Origin-associated Transcriptional Programs in Diffuse Large B-cell LymphomaSemantic proximity Read ↗

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.Semantic proximity Read ↗

Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas.Semantic proximity Read ↗

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.Semantic proximity Read ↗

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.