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Article

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression

10 May 2021

Abstract excerpt

The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions for an effective adaptive immune response. However, in addition to the benefits generated by its physiological roles, AID is an etiological factor for the development of human and murine leukemias and lymphomas. This review highlights the...

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Identifiers

PMID: 34041018
DOI: 10.3389/fonc.2021.634383

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AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease ProgressionPMID 34041018Read ↗

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Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the cloneSemantic proximity Read ↗

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