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Article

A practical guide for mutational signature analysis in hematological malignancies

5 Jul 2019

Abstract excerpt

Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequencing of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia, we compare the performance of public signature...

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PMID: 31278357
DOI: 10.1038/s41467-019-11037-8

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