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Article

Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021

Zhao Chuan-Rong, Yang Fang-Fang, Cui Qinghua, Wang Dong, Zhou Yiran, Li Yi-Shuan, Zhang Yun-Peng, Tang Run-Ze, Yao Wei-Juan, Wang Xiaohong, Pang Wei, Zhao Jia-Nan, Jiang Zhi-Tong, Zhu Juan-Juan, Chien Shu, Zhou Jing

Abstract excerpt

Vascular endothelial cells are exposed to shear stresses with disturbed vs. laminar flow patterns, which lead to proinflammatory vs. antiinflammatory phenotypes, respectively. Effective treatment against endothelial inflammation and the consequent atherogenesis requires the identification of new therapeutic molecules and the development of drugs targeting these molecules. Using Connectivity Map, we have...

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Identifiers

PMID: 34810252
DOI: 10.1073/pnas.2115158118
PMCID: PMC8640790

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