Article

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome

2025-03-14

Abstract excerpt

<h4>Background</h4> Endothelial cells respond to forces generated by laminar blood flow with changes in vasodilation, anticoagulant, fibrinolytic, or anti-inflammatory functions which preserve vessel patency. These responses to flow sheer stress are primarily mediated by the modulation of transcription factors Krüppel-like factors 2 and 4 (KLF2 and KLF4). Notably, disturbed flow patterns, which are found in vascu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f016881-6408-50a8-adef-9c0e4208a7aa
DOI: 10.1101/2025.03.12.642862

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeDOI 10.1101/2025.03.12.642862Read

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.Semantic proximity Read

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and AtherosclerosisSemantic proximity Read

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cellsSemantic proximity Read

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.Semantic proximity Read

Endothelial MRG15 Is a Mechanosensitive Suppressor of AtherosclerosisSemantic proximity Read

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic PotentialSemantic proximity Read

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity Read

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodelingSemantic proximity Read

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.Semantic proximity Read

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear StressSemantic proximity Read

Endothelial fluid shear stress sensing in vascular health and diseaseSemantic proximity Read

Krüppel-like factors in endothelial cell biologySemantic proximity Read