Article

Aortic valve stenosis promotes pathological shear stress-dependent epigenomic dysregulation in circulating T cells

2026-05-19

Abstract excerpt

<h4>Background</h4> Calcific aortic valve stenosis (AVS) is the most prevalent valvular heart disease in Western adults, yet no disease-modifying therapy exists. High shear stress (HSS) generated by progressive valvular obstruction drives endothelial injury and immune-mediated inflammation, but the contribution of circulating T cells to AVS pathogenesis remains poorly defined. <h4>Objectives</h4> We tested wheth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e759e82-1e4b-57b6-ab9f-c8ae1c0ea893
DOI: 10.64898/2026.05.17.722103

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aortic valve stenosis promotes pathological shear stress-dependent epigenomic dysregulation in circulating T cellsDOI 10.64898/2026.05.17.722103Read

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulationSemantic proximity Read

Genetic and Epigenetic Regulation of Inflammatory Genes Drives Calcific Aortic Valve Disease (CAVD)Semantic proximity Read

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cellsSemantic proximity Read

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Semantic proximity Read

Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections.Semantic proximity Read

Cellular-Resolution Spatial Transcriptomics Reveals Laminar VSMC Phenotypic Remodeling and a Hypoxic Medial Core in Human Thoracic Aortic DissectionSemantic proximity Read

Exploring the Causal Effects of Shear Stress Associated DNA Methylation on Cardiovascular RiskSemantic proximity Read

Multi-Omics Analysis of Genetic Drivers Linking Aortic Stenosis and Left Ventricular Diastolic Dysfunction in Heart FailureSemantic proximity Read

Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy.Semantic proximity Read

Matrix stiffness shifts the endothelial shear stress set point for angiogenic activationSemantic proximity Read

Dysregulated smooth muscle cell proliferation and gene expression underlie ACTA2 variant-associated aortopathy.Semantic proximity Read

Epigenetic Biomarkers in Thoracic Aortic Aneurysm, Dissection, and Bicuspid Aortopathy: A Comprehensive ReviewSemantic proximity Read