Article

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells

2025-10-11

Abstract excerpt

<h4>Background</h4> Atherosclerosis develops at arterial sites exposed to disturbed flow, while plaque rupture and plaque erosion predominantly occur in regions subjected to elevated flow. The impact of elevated flow on regulation of endothelial gene expression is less well studied; therefore, we undertook a comprehensive analysis of primary human coronary artery endothelial cell (HCAEC) gene expression under ele...

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Literature Corpus work: 216530d7-79c1-5c79-a967-12d7452845ca
DOI: 10.1101/2025.10.10.681055

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