Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells

25 Jun 2011

Abstract excerpt

The role of endothelial cells (ECs) in aortic valve (AV) disease remains relatively unknown; however, disease preferentially occurs in the fibrosa. We hypothesized oscillatory shear (OS) present on the fibrosa stimulates ECs to modify mRNAs and microRNAs (miRNAs) inducing disease. Our goal was to identify mRNAs and miRNAs differentially regulated by OS and laminar shear (LS) in human AVECs (HAVECs) from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Disease and Treatment Approaches
Share to Cardiac Valve Diseases and Treatments
Share to Coronary Interventions and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21705672
DOI: 10.1152/ajpheart.00117.2011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cellsPMID 21705672Read ↗

Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA SequencingSemantic proximity Read ↗

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cellsSemantic proximity Read ↗

Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery–on–a–chipSemantic proximity Read ↗

Aortic valve stenosis promotes pathological shear stress-dependent epigenomic dysregulation in circulating T cellsSemantic proximity Read ↗

Serial analysis of the vascular endothelial transcriptome under static and shear stress conditionsSemantic proximity Read ↗

Fluid Mechanics, Arterial Disease, and Gene ExpressionSemantic proximity Read ↗

Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress.Semantic proximity Read ↗

Gene expression profiling of acute type A aortic dissection combined with in vitro assessment†Semantic proximity Read ↗

Matrix stiffness shifts the endothelial shear stress set point for angiogenic activationSemantic proximity Read ↗

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculatureSemantic proximity Read ↗

Shear Stress Modulates Inflammatory Responses in Porcine Endothelial Cells Contributing to the Fibrotic Response of Porcine Cardiac FibroblastsSemantic proximity Read ↗

Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.