Article

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

2024-01-17

Abstract excerpt

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide 1 . Laminar shear stress (LSS) from blood flow in straight regions of arteries protects against ASCVD by upregulating the Klf2/4 anti-inflammatory program in endothelial cells (ECs) 2–8 . Conversely, disturbed shear stress (DSS) at curves or branches predisposes these regions to plaque formation 9,10 . We previously repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b45e304b-a0ac-55e2-95dd-e788e89e9bde
DOI: 10.1101/2024.01.16.575958

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosisDOI 10.1101/2024.01.16.575958Read

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerabilitySemantic proximity Read

Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosisSemantic proximity Read

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity Read

JAG1-NOTCH4 Mechanosensing Drives AtherosclerosisSemantic proximity Read

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity Read

Multifaceted Role of Notch Signaling in Vascular Health and DiseasesSemantic proximity Read

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear StressSemantic proximity Read

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.Semantic proximity Read

Endothelial fluid shear stress sensing in vascular health and diseaseSemantic proximity Read

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and AtherosclerosisSemantic proximity Read

Serial analysis of the vascular endothelial transcriptome under static and shear stress conditionsSemantic proximity Read

A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity Read