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Systems biology analysis of longitudinal functional response of endothelial cells to shear stress

26 Sept 2017

Abstract excerpt

Blood flow and vascular shear stress patterns play a significant role in inducing and modulating physiological responses of endothelial cells (ECs). Pulsatile shear (PS) is associated with an atheroprotective endothelial phenotype, while oscillatory shear (OS) is associated with an atheroprone endothelial phenotype. Although mechanisms of endothelial shear response have been extensively studied, most studies...

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PMID: 28973892
DOI: 10.1073/pnas.1707517114

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