Article

Lower shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps <i>via</i> Piezo1-mediated mechanosensation

2023-02-21

Abstract excerpt

<h4>BACKGROUND</h4> Atherosclerosis is a chronic lipid-driven inflammatory disease, largely influenced by hemodynamics. Neutrophil extracellular traps (NETs)-mediated inflammation plays an important role in atherosclerosis. However, little is known about the mechanism of the generation of NETs under different shear stress and subsequent damage to endothelial cells. We sought to identify a novel mechanical signal...

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Literature Corpus work: 7f26498d-0e2b-5f46-a3a3-6c1bf4024819
DOI: 10.1101/2023.02.19.529165

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