Article

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

2023-10-25

Abstract excerpt

Fluid shear stress (FSS) from blood flow is sensed by vascular endothelial cells (ECs) to determine vessel stability, remodeling and susceptibility to atherosclerosis and other inflammatory diseases but the regulatory networks that govern these behaviors are only partially understood. We used cSTAR, a powerful new computational method, to define EC transcriptomic states under low shear stress (LSS) that triggers v...

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Identifiers and source

Literature Corpus work: e1775118-e084-58bd-8212-32cae882cc60
DOI: 10.1101/2023.10.24.563764

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