Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.

doi:10.1016/j.jep.2024.118896

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Article

Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.

Journal of ethnopharmacology - 30 Jan 2025

Fan Yadong, Jialiken Dinala, Zheng Ziwen, Zhang Weiting, Zhang Siqi, Zheng Yawei, Sun Zeqi, Zhang Haitao, Yan Xiwu, Liu Ming, Fang Zhuyuan

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Qianyang Yuyin granules (QYYY) have been used clinically to treat hypertension for over two decades. Previous clinical trials have shown that QYYY can improve vascular elastic function in hypertensive patients. However, the underlying pharmacological mechanism is unclear. AIM OF THE STUDY: To elucidate the effects and mechanisms of QYYY on vascular remodeling using a...

Topics

Animals
Vascular Remodeling
Hypertension
Drugs, Chinese Herbal
Male
Muscle, Smooth, Vascular
Mice, Inbred C57BL
Myocytes, Smooth Muscle
Mice
Antihypertensive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Humans

Molecular Docking Simulation

Blood Pressure

Angiotensin II

Network Pharmacology

Signal Transduction

Apoptosis

Source

Open in PubMed

Identifiers

PMID: 39393558
DOI: 10.1016/j.jep.2024.118896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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