Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro characterization of six hepatitis B virus genotypes from clinical isolates using transfecting linear HBV genomes.

The Journal of general virology - 1 Nov 2021

Zafrullah Mohammad, Vazquez Carlos, Mixson-Hayden Tonya, Purdy Michael A

Abstract excerpt

Hepatitis B virus (HBV) infection is a global public health problem with about 257 million chronically infected people and over 887000 deaths annually. In this study, 32 whole HBV genomes of various genotypes were amplified from clinical isolates to create transfection clones. The clones were sequenced, and their biological properties characterized by transfecting linear HBV clones into HepG2 cells. We analysed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Genotype

Share to Hepatitis B

Share to Hepatitis B virus

Share to Phylogeny

Share to Transfection

Source

Identifiers

PMID: 34723786
DOI: 10.1099/jgv.0.001675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro characterization of six hepatitis B virus genotypes from clinical isolates using transfecting linear HBV genomes.PMID 34723786Read ↗

The Envelope Gene of Hepatitis B Virus Is Implicated in Both Differential Virion Secretion and Genome Replication Capacities between Genotype B and Genotype C Isolates.Semantic proximity Read ↗

Permissive, in vitro replication of hepatitis B virus genotype E.Semantic proximity Read ↗

RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant.Semantic proximity Read ↗

Replication efficiency and sequence analysis of full-length hepatitis B virus isolates from hepatocellular carcinoma tissues.Semantic proximity Read ↗

Characterization of contrasting features between hepatitis B virus genotype A and genotype D in small envelope protein expression and surface antigen secretion.Semantic proximity Read ↗

Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.Semantic proximity Read ↗

In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates.Semantic proximity Read ↗

An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.Semantic proximity Read ↗

RNA Interference inhibits hepatitis B virus of different genotypes in vitro and in vivo.Semantic proximity Read ↗

An improved method for simple and efficient hepatitis B virus genome cloning.Semantic proximity Read ↗

Novel recombinant hepatitis B virus vectors efficiently deliver protein and RNA encoding genes into primary hepatocytes.Semantic proximity Read ↗

Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.