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In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates.

Virologica Sinica - 1 Jun 2022

Liu Tingting, Liu Anlei, Liu Yong, Cen Shan, Zhang Quan

Abstract excerpt

Hepatitis B virus (HBV) genotype B and C are two major genotypes that are prevalent in Asia and differ in natural history and disease progression. The impact of HBV genotypes on viral replication and protein expression has been explored by the transfection of hepatoma cells with replication-competent HBV DNA, which mimics the later stages of the viral life cycle. However, the influence of HBV genotypes on the...

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PMID: 35314401
DOI: 10.1016/j.virs.2022.03.008
PMCID: PMC9243618

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