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Article

Permissive, in vitro replication of hepatitis B virus genotype E.

Journal of virological methods - 1 May 2017

Ji Xin, Zafrullah Mohammad, Wiese Nicholas, Hayden-Mixon Tonya, Forbi Joseph C, Teo Chong-Gee, Purdy Michael A

Abstract excerpt

A cloned stable cell line, HepG2-HBVE6, was established following transfection of HepG2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis B virus (HBV) belonging to genotype E (HBV/E) was inserted. The cell line retains the entire HBV/E insert, and produces episomal HBV DNA. It expresses HBV pregenomic, preS1 and preS2/S transcripts, and sheds hepatitis B surface and e antigens...

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PMID: 28122202
DOI: 10.1016/j.jviromet.2017.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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