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Article

Novel recombinant hepatitis B virus vectors efficiently deliver protein and RNA encoding genes into primary hepatocytes.

Journal of virology - 1 Jun 2013

Hong Ran, Bai Weiya, Zhai Jianwei, Liu Wei, Li Xinyan, Zhang Jiming, Cui Xiaoxian, Zhao Xue, Ye Xiaoli, Deng Qiang, Tiollais Pierre, Wen Yumei, Liu Jing, Xie Youhua

Abstract excerpt

Hepatitis B virus (HBV) has extremely restricted host and hepatocyte tropism. HBV-based vectors could form the basis of novel therapies for chronic hepatitis B and other liver diseases and would also be invaluable for the study of HBV infection. Previous attempts at developing HBV-based vectors encountered low yields of recombinant viruses and/or lack of sufficient infectivity/cargo gene expression in primary...

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Identifiers

PMID: 23552416
DOI: 10.1128/JVI.03328-12
PMCID: PMC3676104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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