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Article

RNA Interference inhibits hepatitis B virus of different genotypes in vitro and in vivo.

BMC microbiology - 10 Aug 2010

Zhang Ya-Li, Cheng Tong, Cai Yi-Jun, Yuan Quan, Liu Che, Zhang Tao, Xia De-Zhen, Li Rui-Yin, Yang Lian-Wei, Wang Ying-Bin, Yeo Anthony E T, Shih James Wai-Kuo, Zhang Jun, Xia Ning-Shao

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) infection increases the risk of liver disease and hepatocellular carcinoma. Small interfering RNA (siRNA) can be a potential new tool for HBV therapy. Given the high heterogeneity of HBV strains and the sensitivity towards sequences changes of siRNA, finding a potent siRNA inhibitor against the conservative site on the HBV genome is essential to ensure a therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20696079
DOI: 10.1186/1471-2180-10-214
PMCID: PMC2927532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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