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The Envelope Gene of Hepatitis B Virus Is Implicated in Both Differential Virion Secretion and Genome Replication Capacities between Genotype B and Genotype C Isolates.

Viruses - 28 Mar 2017

Jia Haodi, Qin Yanli, Chen Chaoyang, Zhang Fei, Li Cheng, Zong Li, Wang Yongxiang, Zhang Jiming, Li Jisu, Wen Yumei, Tong Shuping

Abstract excerpt

Chronic infection by hepatitis B virus (HBV) genotype C is associated with a prolonged replicative phase and an increased risk of liver cancer, compared with genotype B infection. We previously found lower replication capacity but more efficient virion secretion by genotype C than genotype B isolates. Virion secretion requires interaction between core particles and ENVELOPE proteins. In the present study,...

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Identifiers

PMID: 28350327
DOI: 10.3390/v9040062
PMCID: PMC5408668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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