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Article

Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C.

Gut - 1 Mar 2021

Li Jing, Li Jisu, Chen Shiqi, Yuan Quan, Zhang Jing, Wu Jingwen, Jiang Qirong, Wang Qianru, Xia Ning-Shao, Zhang Jiming, Tong Shuping

Abstract excerpt

BACKGROUND AND AIMS: Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently arises during chronic infection with HBV genotypes B and C. Since the second ATG is 33nt downstream, they truncate large (L) envelope protein by 11 residues like wild-type genotype D. This study characterised their functional consequences. METHODS: HBV genomes with or without deletion were amplified from a patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32571971
DOI: 10.1136/gutjnl-2019-320096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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