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Article

Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.

PloS one - 1 Jan 2016

Chen Jianhong, Liu Yan, Zhao Jun, Xu Zhihui, Chen Rongjuan, Si Lanlan, Lu Shanshan, Li Xiaodong, Wang Shuai, Zhang Kai, Li Jin, Han Juqiang, Xu Dongping

Abstract excerpt

OBJECTIVE: The impact of hepatitis B virus (HBV) preS/S-gene mutations on occult HBV infection (OBI) is not fully understood. This study characterized multiple novel HBV preS/S-gene mutants obtained from an OBI patient. METHODS: PreS/S-gene mutants were analyzed by clonal sequencing. Viral replication and expression were analyzed by transfecting HBV genomic recombinants into HepG2 cells. RESULTS: Twenty-one...

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Identifiers

PMID: 27182775
DOI: 10.1371/journal.pone.0155654
PMCID: PMC4868315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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