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Article

Deciphering the Clonal Origin of Relapsed Acute Lymphoblastic Leukemia in Children.

Blood cancer discovery - 1 Jul 2020

Ogawa Seishi

Abstract excerpt

In this issue of Blood Cancer Discovery, Waanders and colleagues characterize somatic alterations in a large cohort of relapsed pediatric acute lymphoblastic leukemia (ALL). This comprehensive genomic analysis reveals mutations distinctly associated with primary disease versus response to therapy. In the reconstructed clonal evolution scenarios, relapsed leukemic cells propagate from clones already expanded at...

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Identifiers

PMID: 34661139
DOI: 10.1158/2643-3249.BCD-20-0056
PMCID: PMC8500729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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