Article
Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia.
Scientific reports - 6 Aug 2021
Sayyab Shumaila, Lundmark Anders, Larsson Malin, Ringnér Markus, Nystedt Sara, Marincevic-Zuniga Yanara, Tamm Katja Pokrovskaja, Abrahamsson Jonas, Fogelstrand Linda, Heyman Mats, Norén-Nyström Ulrika, Lönnerholm Gudmar, Harila-Saari Arja, Berglund Eva C, Nordlund Jessica, Syvänen Ann-Christine
Abstract excerpt
The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individually matched remission samples as controls, and allelic expression...
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