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Article

Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy.

Blood advances - 13 Feb 2018

Spinella Jean-François, Richer Chantal, Cassart Pauline, Ouimet Manon, Healy Jasmine, Sinnett Daniel

Abstract excerpt

Childhood acute lymphoblastic leukemia (cALL) is the most frequent pediatric cancer. Refractory/relapsed cALL presents a survival rate of ∼45% and is still one of the leading causes of death by disease among children. Mechanisms, such as clonal competition and evolutionary adaptation, govern treatment resistance. However, the underlying clonal dynamics leading to multiple relapses and differentiating early (<36...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29365312
DOI: 10.1182/bloodadvances.2017011510
PMCID: PMC5812325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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