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Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.

Leukemia - 1 Jul 2022

Richter-Pechańska Paulina, Kunz Joachim B, Rausch Tobias, Erarslan-Uysal Büşra, Bornhauser Beat, Frismantas Viktoras, Assenov Yassen, Zimmermann Martin, Happich Margit, von Knebel-Doeberitz Caroline, von Neuhoff Nils, Köhler Rolf, Stanulla Martin, Schrappe Martin, Cario Gunnar, Escherich Gabriele, Kirschner-Schwabe Renate, Eckert Cornelia, Avigad Smadar, Pfister Stefan M, Muckenthaler Martina U, Bourquin Jean-Pierre, Korbel Jan O, Kulozik Andreas E

Abstract excerpt

The mechanisms underlying T-ALL relapse remain essentially unknown. Multilevel-omics in 38 matched pairs of initial and relapsed T-ALL revealed 18 (47%) type-1 (defined by being derived from the major ancestral clone) and 20 (53%) type-2 relapses (derived from a minor ancestral clone). In both types of relapse, we observed known and novel drivers of multidrug resistance including MDR1 and MVP, NT5C2 and JAK-STAT...

Topics

Child
Clonal Evolution
Humans
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Recurrence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35585141
DOI: 10.1038/s41375-022-01587-0
PMCID: PMC9252914

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