Article

Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease Relapse

2025-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Relapse remains the leading cause of mortality in pediatric acute myeloid leukemia (AML), yet the genetic changes contributing to relapse remain incompletely defined. To address this gap, we performed whole-genome sequencing and targeted-capture sequencing on 39 diagnosis–relapse and 2 relapse–relapse pairs of pediatric AML. Mutational burden increased at relapse, largely reflecting spontaneous...

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Literature Corpus work: 64a4d2ed-7ced-59a3-ad28-cf4b9f8848a9
DOI: 10.1101/2025.11.04.25339472

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