Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia.

doi:10.3390/genes12020214

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Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia.

Genes - 2 Feb 2021

Antić Željko, Lelieveld Stefan H, van der Ham Cédric G, Sonneveld Edwin, Hoogerbrugge Peter M, Kuiper Roland P

Abstract excerpt

Pediatric acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is characterized by clonal heterogeneity. Genomic mutations can increase proliferative potential of leukemic cells and cause treatment resistance. However, mechanisms driving mutagenesis and clonal diversification in ALL are not fully understood. In this proof of principle study, we performed whole genome sequencing of two...

Topics

APOBEC Deaminases
Alleles
Child
Child, Preschool
Clonal Evolution
DNA Damage
DNA Mutational Analysis
Female
Gene Expression Regulation, Neoplastic
Gene Frequency
Genetic Heterogeneity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Humans

Male

Mutagenesis

Mutation

Pediatrics

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 33540666
DOI: 10.3390/genes12020214
PMCID: PMC7913080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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