Article
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016
Oshima Koichi, Khiabanian Hossein, da Silva-Almeida Ana C, Tzoneva Gannie, Abate Francesco, Ambesi-Impiombato Alberto, Sanchez-Martin Marta, Carpenter Zachary, Penson Alex, Perez-Garcia Arianne, Eckert Cornelia, Nicolas Concepción, Balbin Milagros, Sulis Maria Luisa, Kato Motohiro, Koh Katsuyoshi, Paganin Maddalena, Basso Giuseppe, Gastier-Foster Julie M, Devidas Meenakshi, Loh Mignon L, Kirschner-Schwabe Renate, Palomero Teresa, Rabadan Raul, Ferrando Adolfo A
Abstract excerpt
Although multiagent combination chemotherapy is curative in a significant fraction of childhood acute lymphoblastic leukemia (ALL) patients, 20% of cases relapse and most die because of chemorefractory disease. Here we used whole-exome and whole-genome sequencing to analyze the mutational landscape at relapse in pediatric ALL cases. These analyses identified numerous relapse-associated mutated genes intertwined...
Topics
- Base Sequence
- Cell Line, Tumor
- Clonal Evolution
- Drug Resistance, Neoplasm
- Genes, ras
- Humans
- Methotrexate