Article
Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia.
Blood cancer discovery - 1 Jul 2020
Waanders Esmé, Gu Zhaohui, Dobson Stephanie M, Antić Željko, Crawford Jeremy Chase, Ma Xiaotu, Edmonson Michael N, Payne-Turner Debbie, van de Vorst Maartje, Jongmans Marjolijn C J, McGuire Irina, Zhou Xin, Wang Jian, Shi Lei, Pounds Stanley, Pei Deqing, Cheng Cheng, Song Guangchun, Fan Yiping, Shao Ying, Rusch Michael, McCastlain Kelly, Yu Jiangyan, van Boxtel Ruben, Blokzijl Francis, Iacobucci Ilaria, Roberts Kathryn G, Wen Ji, Wu Gang, Ma Jing, Easton John, Neale Geoffrey, Olsen Scott R, Nichols Kim E, Pui Ching-Hon, Zhang Jinghui, Evans William E, Relling Mary V, Yang Jun J, Thomas Paul G, Dick John E, Kuiper Roland P, Mullighan Charles G
Abstract excerpt
Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood death. Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. However, the genomic landscape, evolutionary trajectories and mutational mechanisms driving relapse are incompletely understood. In an analysis of 92 cases of relapsed childhood ALL, incorporating multimodal...
Topics
- Child
- Clonal Evolution
- Genomics
- Humans
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma