Article
Clonal evolution of acute leukemia genomes.
Oncogene - 10 Jan 2013
Jan M, Majeti R
Abstract excerpt
In large part, cancer results from the accumulation of multiple mutations in a single cell lineage that are sequentially acquired and subject to an evolutionary process where selection drives the expansion of more fit subclones. Owing to the technical challenge of distinguishing and isolating distinct cancer subclones, many aspects of this clonal evolution are poorly understood, including the diversity of...
Topics
- Clonal Evolution
- Clone Cells
- Disease Progression
- Genetic Variation
- Genome, Human
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Oncogene Proteins, Fusion
- Polymorphism, Single Nucleotide
- Precursor Cell Lymphoblastic Leukemia-Lymphoma