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Article

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

Science (New York, N.Y.) - 28 Nov 2008

Mullighan Charles G, Phillips Letha A, Su Xiaoping, Ma Jing, Miller Christopher B, Shurtleff Sheila A, Downing James R

Abstract excerpt

Most children with acute lymphoblastic leukemia (ALL) can be cured, but the prognosis is dismal for the minority of patients who relapse after treatment. To explore the genetic basis of relapse, we performed genome-wide DNA copy number analyses on matched diagnosis and relapse samples from 61 pediatric patients with ALL. The diagnosis and relapse samples typically showed different patterns of genomic copy number...

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PMID: 19039135
DOI: 10.1126/science.1164266
PMCID: PMC2746051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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