Article
Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.
Nature communications - 19 Mar 2015
Ma Xiaotu, Edmonson Michael, Yergeau Donald, Muzny Donna M, Hampton Oliver A, Rusch Michael, Song Guangchun, Easton John, Harvey Richard C, Wheeler David A, Ma Jing, Doddapaneni HarshaVardhan, Vadodaria Bhavin, Wu Gang, Nagahawatte Panduka, Carroll William L, Chen I-Ming, Gastier-Foster Julie M, Relling Mary V, Smith Malcolm A, Devidas Meenakshi, Guidry Auvil Jaime M, Downing James R, Loh Mignon L, Willman Cheryl L, Gerhard Daniela S, Mullighan Charles G, Hunger Stephen P, Zhang Jinghui
Abstract excerpt
There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymphoblastic leukaemias from diagnosis to relapse. We show that clonal diversity is comparable at diagnosis and relapse and clonal survival from diagnosis to relapse is not associated with...
Topics
- 5'-Nucleotidase
- CREB-Binding Protein
- Child
- Clonal Evolution
- Clone Cells
- DNA Copy Number Variations
- Disease Progression
- Exome