Article
Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets.
EBioMedicine - 1 Oct 2021
Nanus Dominika E, Badoume Amel, Wijesinghe Susanne N, Halsey Andrea M, Hurley Patrick, Ahmed Zubair, Botchu Rajesh, Davis Edward T, Lindsay Mark A, Jones Simon W
Abstract excerpt
BACKGROUND: Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether synovial tissue from areas associated with pain exhibited different synovial fibroblast subsets, compared to synovial tissue from sites not associated with pain. A further aim was to compare differences between early and end-stage disease...
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