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Article

Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes.

Cartilage - 1 Jan 2022

Mantripragada Venkata P, Csorba Alexander, Bova Wesley, Boehm Cynthia, Piuzzi Nicolas S, Bullen Jennifer, Midura Ronald J, Muschler George F

Abstract excerpt

OBJECTIVE: Clinical heterogeneity of primary osteoarthritis (OA) is a major challenge in understanding pathogenesis and development of targeted therapeutic strategies. This study aims to (1) identify OA patient subgroups phenotypes and (2) determine predictors of OA severity and cartilage-derived stem/progenitor concentration using clinical-, tissue-, and cell- level metrics. DESIGN: Cartilage, synovium (SYN) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35109693
DOI: 10.1177/19476035221074003
PMCID: PMC9137310

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KL
PCTP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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