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Article

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis.

Frontiers in immunology - 1 Jan 2024

Damerau Alexandra, Rosenow Emely, Alkhoury Dana, Buttgereit Frank, Gaber Timo

Abstract excerpt

Osteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane. Activated fibroblast-like synoviocytes (FLS) of the synovial membrane have been identified as key drivers, secreting humoral mediators that maintain inflammatory processes, proteases that cause cartilage and bone destruction, and...

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Identifiers

PMID: 38895122
DOI: 10.3389/fimmu.2024.1385006
PMCID: PMC11183113

Genes

THY1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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