Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis

Abstract excerpt

Background Chondrocytes and synovial cells participate in the pathogenesis of osteoarthritis (OA). Nonetheless, the interactions and correlations between OA synovial cells and chondrocytes remain unclear. This study aims to elucidate the interactions and correlations between OA synovial cells and chondrocytes, so as to deepen understanding of OA pathogenesis. Methods Single-cell sequencing analysis was employed...

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