Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.

JCI insight - 23 Jan 2025

Miyahara Junya, Omata Yasunori, Chijimatsu Ryota, Okada Hiroyuki, Ishikura Hisatoshi, Higuchi Junya, Tachibana Naohiro, Nagata Kosei, Tani Shoichiro, Kono Kenichi, Kawaguchi Kohei, Yamagami Ryota, Inui Hiroshi, Taketomi Shuji, Iwanaga Yasuhide, Terashima Asuka, Yano Fumiko, Seki Masahide, Suzuki Yutaka, Baron Roland, Tanaka Sakae, Saito Taku

Abstract excerpt

Osteoarthritis (OA) shows various clinical manifestations depending on the status of its joint components. We aimed to identify the synovial cell subsets responsible for OA pathophysiology by comprehensive analyses of human synovium samples in single-cell resolution. Two distinct OA synovial tissue groups were classified by gene expression profiles in RNA-Seq: inflammatory and fibrotic. The inflammatory group...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Fibrosis

Share to Macrophages

Share to Osteoarthritis, Knee

Share to Phenotype

Share to Synovial Membrane

Source

Open in PubMed Open full text

Identifiers

PMID: 39846253
DOI: 10.1172/jci.insight.183690
PMCID: PMC11790023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.PMID 39846253Read ↗

Distinct subsets of synovial fibroblasts control cartilage destruction in joint diseases.Semantic proximity Read ↗

Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritisSemantic proximity Read ↗

Fibroblast pathology in inflammatory joint diseaseSemantic proximity Read ↗

Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integrationSemantic proximity Read ↗

Single Cell Transcriptomics and Flow Cytometry Reveal Disease-associated Fibroblast Subsets in Rheumatoid ArthritisSemantic proximity Read ↗

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritisSemantic proximity Read ↗

Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritisSemantic proximity Read ↗

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritisSemantic proximity Read ↗

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritisSemantic proximity Read ↗

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis.Semantic proximity Read ↗

A reference single-cell map of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective synovial biopsy collectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.