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Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis.

Osteoarthritis and cartilage - 1 May 2020

Miller R E, Tran P B, Ishihara S, Syx D, Ren D, Miller R J, Valdes A M, Malfait A M

Abstract excerpt

OBJECTIVE: Following destabilization of the medial meniscus (DMM), mice develop experimental osteoarthritis (OA) and associated pain behaviors that are dependent on the stage of disease. We aimed to describe changes in gene expression in knee-innervating dorsal root ganglia (DRG) after surgery, in order to identify molecular pathways associated with three pre-defined pain phenotypes: "post-surgical pain",...

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Arthralgia
Arthritis, Experimental
Ganglia, Spinal
Immunity, Innate
Microarray Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoarthritis, Knee

Pain, Postoperative

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Identifiers

PMID: 31982564
DOI: 10.1016/j.joca.2020.01.008
PMCID: PMC7214125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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