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Fibroblast–Myofibroblast Transition in Osteoarthritis Progression: Current Insights

15 Aug 2025

Abstract excerpt

Osteoarthritis (OA) is a multifactorial joint disease traditionally characterized by cartilage degradation, while growing evidence underscores the critical role of synovial fibrosis in driving disease progression. The synovium exhibits pathological remodeling in OA, primarily due to the phenotypic transition of fibroblast-like synoviocytes (FLSs) into myofibroblasts. This fibroblast-myofibroblast transition (FMT)...

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PMID: 40869202
DOI: 10.3390/ijms26167881

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