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Article

Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways

2 Jul 2025

Abstract excerpt

Osteoarthritis of the ankle is a debilitating condition affecting nearly 20% of adults in the United States. The tissue, cellular, and molecular basis of this disease remains poorly understood, particularly the role of the synovial membrane. This prospective case-control study examined the gene expression profile of synovial tissue in ankle osteoarthritis to uncover biological pathways altered in the disease....

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PMID: 40605342
DOI: 10.1002/jor.70016

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