Article
Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways
2 Jul 2025
Abstract excerpt
Osteoarthritis of the ankle is a debilitating condition affecting nearly 20% of adults in the United States. The tissue, cellular, and molecular basis of this disease remains poorly understood, particularly the role of the synovial membrane. This prospective case-control study examined the gene expression profile of synovial tissue in ankle osteoarthritis to uncover biological pathways altered in the disease....
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