Article

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

2026-04-24

Abstract excerpt

<h4>Objectives</h4> To identify synovial transcriptional clusters in human knee osteoarthritis (OA) and determine how these relate to synovial histologic features, cell-type-associated gene expression, and cartilage degeneration severity. <h4>Methods</h4> Bulk RNA sequencing (RNA-seq) of synovial tissue from n = 135 patients with knee OA was analyzed using consensus clustering. Clusters were compared by clinical...

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Literature Corpus work: 8d692932-1664-5829-9824-a9f9985f9120
DOI: 10.64898/2026.04.21.719697

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