Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and pain

Abstract excerpt

This study delineates distinct late-stage osteoarthritis (OA) profiles, characterized by NF-κB, TNF-α, and TGF-β-mediated synovial inflammation and pain, in a cohort of 31 patients undergoing joint arthroplasty. Histopathological analysis demonstrated synoviocyte hyperplasia, increased stromal cellularity, inflammatory infiltrates, and enhanced vascularization, findings that correlated with higher synovitis...

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