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Article

Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.

BMC cancer - 9 Oct 2021

Bjaanæs Maria Moksnes, Nilsen Gro, Halvorsen Ann Rita, Russnes Hege G, Solberg Steinar, Jørgensen Lars, Brustugun Odd Terje, Lingjærde Ole Christian, Helland Åslaug

Abstract excerpt

BACKGROUND: Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence gene expression and further alter signaling pathways. In this study we aimed to characterize the genomic architecture of NSCLC tumors and to identify genomic differences between tumors stratified...

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Source

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Identifiers

PMID: 34625038
DOI: 10.1186/s12885-021-08811-7
PMCID: PMC8501630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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