Article
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.
PloS one - 1 Jan 2012
Thu Kelsie L, Vucic Emily A, Chari Raj, Zhang Wei, Lockwood William W, English John C, Fu Rong, Wang Pei, Feng Ziding, MacAulay Calum E, Gazdar Adi F, Lam Stephen, Lam Wan L
Abstract excerpt
Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified thus far cannot explain all of the clinical and biological disparities observed in lung tumors of NS and smokers. To...
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