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Article

Genomic and transcriptional alterations in lung adenocarcinoma in relation to EGFR and KRAS mutation status.

PloS one - 1 Jan 2013

Planck Maria, Edlund Karolina, Botling Johan, Micke Patrick, Isaksson Sofi, Staaf Johan

Abstract excerpt

INTRODUCTION: In lung adenocarcinoma, the mutational spectrum is dominated by EGFR and KRAS mutations. Improved knowledge about genomic and transcriptional alterations in and between mutation-defined subgroups may identify genes involved in disease development or progression. METHODS: Genomic profiles from 457 adenocarcinomas, including 113 EGFR-mutated, 134 KRAS-mutated and 210 EGFR and KRAS-wild type tumors...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
DNA Copy Number Variations
ErbB Receptors
Female
Genes, ras
Genomics
Humans
Lung Neoplasms
Male
Mutation

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Transcription, Genetic

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Identifiers

PMID: 24205279
DOI: 10.1371/journal.pone.0078614
PMCID: PMC3812039

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24205279-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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