Article
Characterizing the cancer genome in lung adenocarcinoma.
Nature - 6 Dec 2007
Weir Barbara A, Woo Michele S, Getz Gad, Perner Sven, Ding Li, Beroukhim Rameen, Lin William M, Province Michael A, Kraja Aldi, Johnson Laura A, Shah Kinjal, Sato Mitsuo, Thomas Roman K, Barletta Justine A, Borecki Ingrid B, Broderick Stephen, Chang Andrew C, Chiang Derek Y, Chirieac Lucian R, Cho Jeonghee, Fujii Yoshitaka, Gazdar Adi F, Giordano Thomas, Greulich Heidi, Hanna Megan, Johnson Bruce E, Kris Mark G, Lash Alex, Lin Ling, Lindeman Neal, Mardis Elaine R, McPherson John D, Minna John D, Morgan Margaret B, Nadel Mark, Orringer Mark B, Osborne John R, Ozenberger Brad, Ramos Alex H, Robinson James, Roth Jack A, Rusch Valerie, Sasaki Hidefumi, Shepherd Frances, Sougnez Carrie, Spitz Margaret R, Tsao Ming-Sound, Twomey David, Verhaak Roel G W, Weinstock George M, Wheeler David A, Winckler Wendy, Yoshizawa Akihiko, Yu Soyoung, Zakowski Maureen F, Zhang Qunyuan, Beer David G, Wistuba Ignacio I, Watson Mark A, Garraway Levi A, Ladanyi Marc, Travis William D, Pao William, Rubin Mark A, Gabriel Stacey B, Gibbs Richard A, Varmus Harold E, Wilson Richard K, Lander Eric S, Meyerson Matthew
Abstract excerpt
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize copy-number alterations in primary lung adenocarcinomas. By analysis of a large collection of tumours (n = 371) using dense...
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