Article
High-resolution genomic profiles of human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2005
Tonon Giovanni, Wong Kwok-Kin, Maulik Gautam, Brennan Cameron, Feng Bin, Zhang Yunyu, Khatry Deepak B, Protopopov Alexei, You Mingjian James, Aguirre Andrew J, Martin Eric S, Yang Zhaohui, Ji Hongbin, Chin Lynda, Depinho Ronald A
Abstract excerpt
Lung cancer is the leading cause of cancer mortality worldwide, yet there exists a limited view of the genetic lesions driving this disease. In this study, an integrated high-resolution survey of regional amplifications and deletions, coupled with gene-expression profiling of non-small-cell lung cancer subtypes, adenocarcinoma and squamous-cell carcinoma (SCC), identified 93 focal copy-number alterations, of...
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